Varsity Squash competes against teams in the MIAA Conference. The team's home court is Coppermine Racket & Fitness Club. Coach Joe Lacy, entering his 10th season, and the pro from Coppermine hold practices every day in season and the teams usually have two matches a week, including a series of weekly challenge matches within the team. In 2016, the varsity squash team finished in 4th place out of 16 teams in Div. VI at the U.S. Squash High School National Championships in Connecticut. Squash is a lifetime sport, and the goal of the program is to teach the fundamentals of play, as well as teamwork, sportsmanship, character, and respect for the game and the opponent. Loyola's squash program started in 2003 and has steadily grown each year since.
Loyola also has a Squash Club in the Middle School that meets three times a week after school, 2:45 until 3:30, for practices and matches.